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Objective
This study aimed to determine the effects of a multicomponent exercise intervention during the first year post‐bariatric surgery (BS) on body composition, weight loss (WL), energy expenditure, and nutrient intake.
Methods
A total of 84 patients were included in this study and were randomly assigned to either an exercise group (n = 41) or a control group (n = 20). The exercise group participated...
Objective
The objective of this study was to quantify the effects of a 4‐week, supervised, high‐intensity interval training (HIIT) on intrahepatic triglyceride content (IHTG, percentage), cardiorespiratory fitness (CRF), and cardiometabolic markers in adolescents with obesity.
Methods
A total of 40 adolescents (age 13–18 y, BMI 36.7 ± 5.8 kg/m2) at risk for metabolic dysfunction‐associated steatotic...
Objective
Vaspin (visceral adipose tissue derived serine protease inhibitor, SERPINA12) is associated with obesity‐related metabolic traits, but its causative role is still elusive. The role of genetics in serum vaspin variability to establish its causal relationship with metabolically relevant traits was investigated.
Methods
A meta‐analysis of genome‐wide association studies for serum vaspin...
Objective
Obesity is a disorder of excessive adiposity, typically assessed via the anthropometric density measure of BMI. Numerous studies have implicated BMI with differences in brain structure, but with highly inconsistent findings.
Methods
Machine learning elastic net regression models with cross‐validation were conducted to characterize a neuroanatomical morphometry profile associated with...
Objective
The aim of this study was to explore prospective relationships between changing patterns of BMI/waist to height ratio (WHtR) during adolescence and subsequent neurobehavioral development.
Methods
In this prospective cohort study, randomized stratified sampling was used to recruit six middle schools and 609 students in Shanghai, China. In Grades 6, 7, and 9, the Youth Self Report scale...
Objective
This study tested the hypothesis that expression of insulin‐like growth factor 1 (IGF‐1) protein and mRNA splice variants is lower in skeletal muscle of humans with obesity who have a lower mixed‐muscle protein fractional synthesis rate (MMP‐FSR) when compared with individuals without obesity.
Methods
The study included nine participants with obesity (OB, mean [SD], BMI = 35 [3] kg/m...
Objective
Binge‐eating disorder (BED) is a prevalent psychiatric disorder associated with obesity. Few evidence‐based treatments exist for BED, particularly pharmacological options. This study tested the efficacy of naltrexone/bupropion for BED.
Methods
A randomized, double‐blind, placebo‐controlled, 12‐week trial tested naltrexone/bupropion for BED with and without obesity. Eighty‐nine patients...
The body mass index (BMI; weight/height2), providing no information about the relative size of any adipose tissue depots, may accordingly misclassify degrees of cardiometabolic risk. However, in supine persons the abdominal height above the exam table (the sagittal abdominal diameter, SAD) is associated preferentially with the accumulation of visceral fat. Since visceral fat is a marker of insulin...
Objective
This study examined how cumulative BMI (cBMI) is associated with incident prediabetes in a biracial observational cohort study followed from young adulthood to middle age.
Methods
Black and White men and women (n = 4190) from the Coronary Artery Risk Development in Young Adults (CARDIA) study, ages 18 to 30 years in 1985 to 1986 and free of prediabetes or diabetes at baseline, were followed...
Objective
This study aimed to determine the relationship between meeting all three 24‐hour movement recommendations (i.e., physical activity, sleep duration, and screen time) and obesity‐related indicators among young people.
Methods
Four databases were systematically searched (PubMed, Scopus, Web of Science, and Cochrane Library).
Results
Meeting the 24‐hour movement recommendations was cross‐sectionally...
Objective
The aim of this study was to identify predictors of weight regain and continued weight maintenance among individuals already successful at long‐term weight loss in a widely available weight‐management program.
Methods
Participants were 2843 weight‐loss maintainers in WeightWatchers who had maintained weight loss ≥9.1 kg for ≥1 year (average 25.5 kg for 3.5 years; BMI = 26.7 kg/m2). Validated...
Objective
Incretin receptor agonists are now standard of care in treating obesity. Their efficacy and tolerability might be further improved by combining them with compounds that offer orthogonal mechanisms of action. The cannabinoid type 1 receptor (CB1R) is a clinically validated therapeutic target in obesity, and several experimental CB1R inverse agonists have been shown to induce weight loss...
Objective
The aim of this study was to investigate the mediating role of child brain structure in the relationship between prenatal gestational diabetes mellitus (GDM) exposure and child adiposity.
Methods
This was a cross‐sectional study of 9– to 10‐year‐old participants and siblings across the US. Data were obtained from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD)...
Objective
Studies have shown sexual minority women (SMW) have a higher incidence of obesity, but the risk of metabolic syndrome (MetS) in SMW is unclear. We examined the association between sexual orientation and MetS and its components.
Methods
Data were extracted from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2016 examining women aged 20 to 59 years. Participants...
Objective
This study aimed to determine the important clinical management bottlenecks that contribute to underuse of weight loss surgery (WLS) and assess risk factors for attrition at each of them.
Methods
A multistate conceptual model of progression from primary care to WLS was developed and used to study all adults who were seen by a primary care provider (PCP) and eligible for WLS from 2016...
Objective
The study aim was to determine whether (A) differences in executive function (EF) and cognition precede weight gain or (B) weight gain causes changes to EF and cognition.
Methods
Data were gathered from the Adolescent Brain Cognitive Development (ABCD) Study (release 4.0; ages 9–12 years old [N = 2794]; 100% had healthy weight at baseline [i.e., 9/10 years old], 12.4% had unhealthy weight...
Objective
Alström syndrome (AS) is a rare multisystem disorder of which early onset childhood obesity is a cardinal feature. Like humans with AS, animal models with Alms1 loss‐of‐function mutations develop obesity, supporting the notion that ALMS1 is required for the regulatory control of energy balance across species. This study aimed to determine which component(s) of energy balance are reliant...
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